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Article

Computational investigation on the effects of H50Q and G51D mutations on the α-Synuclein aggregation propensity.

Journal of biomolecular structure & dynamics - 1 Jul 2018

Sanjeev Airy, Mattaparthi Venkata Satish Kumar

Abstract excerpt

The aggregation of α-synuclein is linked directly to the histopathology of Parkinson's disease (PD). However, several missense mutations present in the α-synuclein gene (SNCA) have been known to be associated with PD. Several studies have highlighted the effect of SNCA mutations on the α-synuclein aggregation, but their pathological roles are not completely established. In this study, we have focused on the...

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Source

Identifiers

PMID: 28650719
DOI: 10.1080/07391102.2017.1347060

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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