Article

Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations

2025-06-25

Abstract excerpt

Antibiotic resistant bacteria have been a rising clinical concern for decades. Beyond acquisition of alleles conferring resistance, bacteria under stress (e.g., from changing environmental conditions or mutations) can have higher intrinsic resistance to antibiotics than unstressed cells. This concern is expanded for gram-negative bacteria which have a protective outer membrane serving as an additional barrier agai...

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Literature Corpus work: c34188e1-fdc8-5c64-959b-c867cd32d94a
DOI: 10.1101/2025.06.20.660601

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