Article

Reactive oxygen species accelerate <i>de novo</i> acquisition of antibiotic resistance in <i>E. coli</i>

2023-07-22

Abstract excerpt

Reactive oxygen species (ROS) produced as a secondary effect of bactericidal antibiotics are hypothesized to play a role in killing bacteria. However, the role of ROS in the development of de novo resistance as a result of sublethal levels of bactericidal antibiotics has barely been investigated. Here, we report that single-gene knockout strains with reduced ROS scavenging exhibited enhanced ROS accumulation and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5433fc5a-9670-5268-9941-1f72536626f0
DOI: 10.1101/2023.07.21.550122

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactive oxygen species accelerate <i>de novo</i> acquisition of antibiotic resistance in <i>E. coli</i>DOI 10.1101/2023.07.21.550122Read

Antibiotic-Induced Genetic Variation: How It Arises and How It Can Be Prevented.Semantic proximity Read

<i>De novo</i> acquisition of antibiotic resistance in six species of bacteriaSemantic proximity Read

Antibiotics and antibiotic resistance: a bitter fight against evolution.Semantic proximity Read

Role of environmental stresses in elevating resistance mutations in bacteria: Phenomena and mechanisms.Semantic proximity Read

Induction of Bacteriophage PinR Facilitates the Evolution of Antibiotic ResistanceSemantic proximity Read

The role of intracellular ROS in the development of antimicrobial resistance:A convergent mediator linking mutations and horizontal gene transfer.Semantic proximity Read

Anti-microbial resistance and aging-A design for evolution.Semantic proximity Read

Identification of <i>Escherichia coli</i> Genes Essential for High-Level, Clinically Relevant, Resistance to AntibioticsSemantic proximity Read

Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutationsSemantic proximity Read

Experimental evolution reveals the genetic basis and systems biology of superoxide stress toleranceSemantic proximity Read

Sublethal vancomycin-induced ROS mediating antibiotic resistance in <i>Staphylococcus aureus</i>Semantic proximity Read

Mitomycin C Retains Efficacy after Adaptive Laboratory Evolution of <i>Staphylococcus aureus</i>Semantic proximity Read