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Article

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of <i>Klebsiella pneumoniae</i>

2025-02-19

Abstract excerpt

Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem tolerance is associated with formation of cell wall-deficient spheroplasts that readily recover to rod shape and normal growth upon removal of the antibiotic. Bot...

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Literature Corpus work
3caac272-d03a-5bce-a4d3-5cb7d9992a94
DOI
10.1101/2025.02.19.639047
Open publication

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Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of <i>Klebsiella pneumoniae</i>DOI 10.1101/2025.02.19.639047
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