Article
Spontaneous mutation in Escherichia coli containing the dnaE911 DNA polymerase antimutator allele.
Genetics - 1 Oct 1994
Oller A R, Schaaper R M
Abstract excerpt
We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represent uncorrected DNA replication errors. In the present study we analyze the effect of one of these...
Topics
- Base Sequence
- DNA Polymerase III
- Escherichia coli
- Frameshift Mutation
- Genes, Bacterial
- Genes, Dominant
- Genotype
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Point Mutation