Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations.

Abstract excerpt

Antibiotic resistant bacteria have been a major clinical concern for decades. Beyond acquisition of alleles conferring resistance, bacteria under stress (e.g., from changing environmental conditions or mutations) can have higher intrinsic resistance to antibiotics than unstressed cells. This concern is expanded for gram-negative bacteria which have a protective outer membrane that serves as an additional barrier...

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