Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmid expression of mutS, -L and/or -H gene in Escherichia coli dam cells results in strains that display reduced mutation frequency.

Mutation research - 1 Jan 2008

Jacquelín Daniela K, Martina Mariana A, Argaraña Carlos E, Barra José L

Abstract excerpt

Escherichia colidam cells have an active but non-directed mismatch repair system; therefore, assembly of MutSLH complex at a mismatched base pair can result in MutH-mediated cleavage of GATC sites in both DNA strands. Unpaired double-strand breaks on a fraction of the replication errors occurring in dam cells presumably cause cell death, selectively eliminating these putative mutants from the population. We show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Aminopurine
Share to Adenosine Triphosphatases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Genes, Bacterial

Share to MutL Proteins

Share to MutS DNA Mismatch-Binding Protein

Share to Plasmids

Share to Transformation, Bacterial

Source

Identifiers

PMID: 17727900
DOI: 10.1016/j.mrfmmm.2007.07.006

Genes

GATC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmid expression of mutS, -L and/or -H gene in Escherichia coli dam cells results in strains that display reduced mutation frequency.PMID 17727900Read ↗

DNA methylation and mutator genes in Escherichia coli K-12.Semantic proximity Read ↗

Mismatch repair in Gram-positive bacteria.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.Semantic proximity Read ↗

SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and RepairSemantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

Mutants with temperature-sensitive defects in the Escherichia coli mismatch repair system: sensitivity to mispairs generated in vivo.Semantic proximity Read ↗

Dominant negative mutator mutations in the mutL gene of Escherichia coliSemantic proximity Read ↗

Overexpression of MutS impairs DNA mismatch repair and causes cell division defect in <i>E.coli</i>Semantic proximity Read ↗

Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutationsSemantic proximity Read ↗

Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coliSemantic proximity Read ↗

Mismatch repair in the antimutator Escherichia coli mud.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.