Article
Antibiotic-Induced Genetic Variation: How It Arises and How It Can Be Prevented.
Annual review of microbiology - 8 Sept 2018
Blázquez Jesús, Rodríguez-Beltrán Jerónimo, Matic Ivan
Abstract excerpt
By targeting essential cellular processes, antibiotics provoke metabolic perturbations and induce stress responses and genetic variation in bacteria. Here we review current knowledge of the mechanisms by which these molecules generate genetic instability. They include production of reactive oxygen species, as well as induction of the stress response regulons, which lead to enhancement of mutation and...
Topics
- Adaptation, Biological
- Anti-Bacterial Agents
- Bacteria
- Genetic Variation
- Genomic Instability
- Mutation
- Reactive Oxygen Species
- Recombination, Genetic
- Selection, Genetic
- Stress, Physiological