Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration.

Journal of visualized experiments : JoVE - 9 Jan 2020

Matoba Nana, Quiroga Ivana Y, Phanstiel Douglas H, Won Hyejung

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified hundreds of genomic loci that are associated with human traits and disease. However, because the majority of the genome-wide significant (GWS) loci fall onto the non-coding genome, the functional impact of many remain unknown. Three-dimensional chromatin interactions identified by Hi-C or its derivatives can provide useful tools to annotate these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to Genome-Wide Association Study

Source

Open in PubMed Open full text

Identifiers

PMID: 31984958
DOI: 10.3791/60428
PMCID: PMC11659877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration.PMID 31984958Read ↗

Annotating genetic variants to target genes using H-MAGMA.Semantic proximity Read ↗

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read ↗

Enhanced Hi-C Capture Analysis reveals complex regulatory architecture at the <i>PICALM_EED</i> locus for Alzheimer’s diseaseSemantic proximity Read ↗

Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s DiseaseSemantic proximity Read ↗

Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.Semantic proximity Read ↗

Hi-GREx: A 3D Genome–Guided Framework for enhancing Gene Expression Prediction Using Hi-C–Selected Distal SNPsSemantic proximity Read ↗

Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease.Semantic proximity Read ↗

Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin loopingSemantic proximity Read ↗

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traitsSemantic proximity Read ↗

Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin loopingSemantic proximity Read ↗

Long-read sequencing reveals hidden structural complexity within Alzheimer's disease-associated GWAS lociSemantic proximity Read ↗

Genome-wide meta-analysis, fine-mapping, and integrative prioritization identify new Alzheimer’s disease risk genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.