Article

Methylation dynamics in the decades preceding acute myeloid leukaemia

2025-06-27

Abstract excerpt

DNA methylation is emerging as a highly sensitive and specific marker of cancer initiation and progression. How these cancer-specific methylation changes are established in the decades before cancer, however, remains largely unknown. Here, we use a unique collection of longitudinal blood samples collected annually up to 15 years prior to a diagnosis of acute myeloid leukaemia to sensitively track the dynamics of D...

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Literature Corpus work: c2e46b05-7015-5dd1-965b-9fdd8518a1ba
DOI: 10.1101/2025.06.26.661643

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