Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

doi:10.1038/nm.4125

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Article

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Nature medicine - 1 Jul 2016

Li Sheng, Garrett-Bakelman Francine E, Chung Stephen S, Sanders Mathijs A, Hricik Todd, Rapaport Franck, Patel Jay, Dillon Richard, Vijay Priyanka, Brown Anna L, Perl Alexander E, Cannon Joy, Bullinger Lars, Luger Selina, Becker Michael, Lewis Ian D, To Luen Bik, Delwel Ruud, Löwenberg Bob, Döhner Hartmut, Döhner Konstanze, Guzman Monica L, Hassane Duane C, Roboz Gail J, Grimwade David, Valk Peter J M, D'Andrea Richard J, Carroll Martin, Park Christopher Y, Neuberg Donna, Levine Ross, Melnick Ari M, Mason Christopher E

Abstract excerpt

Genetic heterogeneity contributes to clinical outcome and progression of most tumors, but little is known about allelic diversity for epigenetic compartments, and almost no data exist for acute myeloid leukemia (AML). We examined epigenetic heterogeneity as assessed by cytosine methylation within defined genomic loci with four CpGs (epialleles), somatic mutations, and transcriptomes of AML patient samples at...

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PMID: 27322744
DOI: 10.1038/nm.4125
PMCID: PMC4938719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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