Article
A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2024
Lao Zhentang, Ding Ling-Wen, Sun Qiao-Yang, Jia Li, Yan Benedict, Ng Alvin Yu-Jin, Capinpin Sharah Mae, Wang Renwei, Ying Li, Chng Wee Joo, Koeffler H Phillip, Koh Woon-Puay, Yuan Jian-Min, Yang Henry, Goh Yeow Tee, Grigoropoulos Nicholas
Abstract excerpt
PURPOSE: DNA methylation alterations are widespread in acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), some of which appear to have evolved independently of somatic mutations in epigenetic regulators. Although the presence of somatic mutations in peripheral blood can predict the risk of development of AML and MDS, its accuracy remains unsatisfactory. EXPERIMENTAL DESIGN: We performed global...
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