Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic dysregulation in acute myeloid leukemia.

Seminars in hematology - 1 Jun 2025

Schrezenmeier Jens, Huntly B J P

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy defined by the clonal expansion of undifferentiated myeloid blasts with a block in differentiation and aberrant self-renewal. While recurrent genomic mutations are well-documented in AML, epigenetic dysregulation has emerged as an equally pivotal driver of leukemogenesis, a notion corroborated by the frequent recurrence of mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenetics and DNA Methylation

Share to Gene Expression Regulation, Leukemic

Share to Histones

Share to Leukemia, Myeloid, Acute

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40651916
DOI: 10.1053/j.seminhematol.2025.06.003
PMCID: PMC7618481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic dysregulation in acute myeloid leukemia.PMID 40651916Read ↗

Epigenetic alterations in acute myeloid leukemiasSemantic proximity Read ↗

Epigenetic regulators as promising therapeutic targets in acute myeloid leukemiaSemantic proximity Read ↗

Epigenetic Modifications in Acute Myeloid Leukemia: Prognosis, Treatment, and HeterogeneitySemantic proximity Read ↗

Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid LeukemiaSemantic proximity Read ↗

The Epigenetic Landscape of Acute Myeloid LeukemiaSemantic proximity Read ↗

Epigenetics in Hematological Malignancies.Semantic proximity Read ↗

Epigenetic regulators and their impact on therapy in acute myeloid leukemiaSemantic proximity Read ↗

Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical ImplicationsSemantic proximity Read ↗

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia.Semantic proximity Read ↗

Recent Clinical Update of Acute Myeloid Leukemia: Focus on Epigenetic Therapies.Semantic proximity Read ↗

The evolving landscape of epigenetic target molecules and therapies in myeloid cancers: focus on acute myeloid leukemia and myeloproliferative neoplasmsSemantic proximity Read ↗

Clinical developments in epigenetic-directed therapies in acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.