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The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

2020-02-07

Abstract excerpt

We report a systematic analysis of the biological and clinical implications of DNA methylation variability in five categories of B-cell tumors derived from B cells spanning the entire maturation spectrum. We used 2056 primary samples including training and validation series and show that 88% of the human DNA methylome is dynamically modulated under normal and neoplastic conditions. B-cell tumors display both epige...

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Literature Corpus work
2b2d3b95-cf8f-5f13-969a-35a43ab095e6
DOI
10.1101/2020.02.06.937383
Open publication

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The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcomeDOI 10.1101/2020.02.06.937383
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