Article
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.
Frontiers of medicine - 1 Dec 2015
Tan Yuting, Liu Han, Chen Saijuan
Abstract excerpt
Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With therapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.