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Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by mutation of the psychiatric risk gene <i>Cacna1c</i>

2020-05-31

Abstract excerpt

Genetic variation in CACNA1C , which encodes the alpha-1 subunit of Ca V 1.2 L-type voltage-gated calcium channels, is strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. To translate genetics to neurobiological mechanisms and rational therapeutic targets, we investigated the impact of altered Cacna1c dosage on rat cognitive, synaptic and circuit phenotypes implicated...

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Literature Corpus work
c2cdb7ae-f600-5040-a51c-ec34160092c2
DOI
10.1101/2020.05.29.123695
Open publication

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