Article
Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α.
Molecular psychiatry - 1 Aug 2017
Kabir Z D, Che A, Fischer D K, Rice R C, Rizzo B K, Byrne M, Glass M J, De Marco Garcia N V, Rajadhyaksha A M
Abstract excerpt
CACNA1C, encoding the Cav1.2 subunit of L-type Ca2+ channels, has emerged as one of the most prominent and highly replicable susceptibility genes for several neuropsychiatric disorders. Cav1.2 channels play a crucial role in calcium-mediated processes involved in brain development and neuronal function. Within the CACNA1C gene, disease-associated single-nucleotide polymorphisms have been associated with impaired...
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