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Article

Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2022

Smedler Erik, Louhivuori Lauri, Romanov Roman A, Masini Débora, Dehnisch Ellström Ivar, Wang Chungliang, Caramia Martino, West Zoe, Zhang Songbai, Rebellato Paola, Malmersjö Seth, Brusini Irene, Kanatani Shigeaki, Fisone Gilberto, Harkany Tibor, Uhlén Per

Abstract excerpt

The L-type voltage-gated Ca2+ channel gene CACNA1C is a risk gene for various psychiatric conditions, including schizophrenia and bipolar disorder. However, the cellular mechanism by which CACNA1C contributes to psychiatric disorders has not been elucidated. Here, we report that the embryonic deletion of Cacna1c in neurons destined for the cerebral cortex using an Emx1-Cre strategy disturbs spontaneous Ca2+...

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Identifiers

PMID: 35135875
DOI: 10.1073/pnas.2108768119
PMCID: PMC8851547

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