Article
The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.
eNeuro - 1 Jan 2000
Lee Anni S, De Jesús-Cortés Héctor, Kabir Zeeba D, Knobbe Whitney, Orr Madeline, Burgdorf Caitlin, Huntington Paula, McDaniel Latisha, Britt Jeremiah K, Hoffmann Franz, Brat Daniel J, Rajadhyaksha Anjali M, Pieper Andrew A
Abstract excerpt
Genetic variations in CACNA1C, which encodes the Cav1.2 subunit of L-type calcium channels (LTCCs), are associated with multiple forms of neuropsychiatric disease that manifest high anxiety in patients. In parallel, mice harboring forebrain-specific conditional knockout of cacna1c (forebrain-Cav1.2 cKO) display unusually high anxiety-like behavior. LTCCs in general, including the Cav1.3 subunit, have been shown...
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