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Article

Sex-specific effects of Cacna1c haploinsufficiency on object recognition, spatial memory, and reversal learning capabilities in rats.

Neurobiology of learning and memory - 1 Nov 2018

Braun Moria D, Kisko Theresa M, Vecchia Débora Dalla, Andreatini Roberto, Schwarting Rainer K W, Wöhr Markus

Abstract excerpt

The CACNA1C gene is strongly implicated in the etiology of multiple major neuropsychiatric disorders, such as bipolar disorder, major depression, and schizophrenia, with cognitive deficits being a common feature. It is unclear, however, by which mechanisms CACNA1C variants advance the risk of developing neuropsychiatric disorders. This study set out to investigate cognitive functioning in a newly developed...

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Identifiers

PMID: 29800644
DOI: 10.1016/j.nlm.2018.05.012

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