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Article

Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species

28 Sept 2018

Abstract excerpt

Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic variation in CACNA1C contributes to risk for these disorders is however not fully known. Both schizophrenia and bipolar disorder are associated with impairments in reversal...

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PMID: 30304534
DOI: 10.1093/schbul/sby146

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