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Article

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease.

Progress in neurobiology - 1 Oct 2012

Bhat Shambhu, Dao David T, Terrillion Chantelle E, Arad Michal, Smith Robert J, Soldatov Nikolai M, Gould Todd D

Abstract excerpt

One of the most consistent genetic findings to have emerged from bipolar disorder genome wide association studies (GWAS) is with CACNA1C, a gene that codes for the α(1C) subunit of the Ca(v)1.2 voltage-dependent L-type calcium channel (LTCC). Genetic variation in CACNA1C have also been associated with depression, schizophrenia, autism spectrum disorders, as well as changes in brain function and structure in...

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Identifiers

PMID: 22705413
DOI: 10.1016/j.pneurobio.2012.06.001
PMCID: PMC3459072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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