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Article

Genetic variation in CACNA1C affects brain circuitries related to mental illness.

Archives of general psychiatry - 1 Sept 2010

Bigos Kristin L, Mattay Venkata S, Callicott Joseph H, Straub Richard E, Vakkalanka Radhakrishna, Kolachana Bhaskar, Hyde Thomas M, Lipska Barbara K, Kleinman Joel E, Weinberger Daniel R

Abstract excerpt

CONTEXT: The CACNA1C gene (alpha-1C subunit of the L-type voltage-gated calcium channel) has been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of association has not been explored. OBJECTIVE: To identify the neural system mechanism that explains the genetic association between the CACNA1C gene and psychiatric illness using neuroimaging and human brain expression. DESIGN: We...

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Identifiers

PMID: 20819988
DOI: 10.1001/archgenpsychiatry.2010.96
PMCID: PMC3282053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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