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Article

Neuronal deletion of CaV1.2 is associated with sex-specific behavioral phenotypes in mice.

Scientific reports - 22 Dec 2022

Klomp Annette J, Plumb Ashley, Mehr Jacqueline B, Madencioglu Deniz A, Wen Hsiang, Williams Aislinn J

Abstract excerpt

The gene CACNA1C, which encodes the pore forming subunit of the L-type calcium channel CaV1.2, is associated with increased risk for neuropsychiatric disorders including schizophrenia, autism spectrum disorder, major depression, and bipolar disorder. Previous rodent work identified that loss or reduction of CaV1.2 results in cognitive, affective, and motor deficits. Most previous work has either included...

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Identifiers

PMID: 36550186
DOI: 10.1038/s41598-022-26504-4
PMCID: PMC9780340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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