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Article

Gain and loss of function changes in <i>CACNA1C</i> affect neuronal networks through divergent pathways

2025-12-12

Abstract excerpt

<h4>Background</h4> CACNA1C encodes the pore-forming subunit of the L-type calcium channel Cav1.2. Common variants in CACNA1C are associated with psychiatric disorders, while rare single-nucleotide variants cause CACNA1C-related disorder (CRD), a multi-system disorder with symptoms that include autism spectrum disorder (ASD), intellectual disability and seizures. However, the cellular mechanisms linking CACNA1C d...

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Literature Corpus work
4a3650ee-8723-52ea-8812-0fa95a3ee722
DOI
10.64898/2025.12.12.693190
Open publication

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Gain and loss of function changes in <i>CACNA1C</i> affect neuronal networks through divergent pathwaysDOI 10.64898/2025.12.12.693190
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