Article

A chemoproteomic portrait of the oncometabolite fumarate

2018-03-21

Abstract excerpt

Hereditary cancer disorders often provide an important window into novel mechanisms supporting tumor growth and survival. Understanding these mechanisms and developing biomarkers to identify their presence thus represents a vital goal. Towards this goal, here we report a chemoproteomic map of the covalent targets of fumarate, an oncometabolite whose accumulation marks the genetic cancer predisposition syndrome her...

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Literature Corpus work: c2c8aeed-d1a3-5603-adcb-34da7f89f9a4
DOI: 10.1101/285759

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