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Article

Fumarate hydratase as a therapeutic target in renal cancer

1 Aug 2020

Abstract excerpt

Introduction Renal cell carcinoma (RCC) is a heterogeneous group of cancers that can occur sporadically or as a manifestation of various inherited syndromes. Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is one such inherited syndrome that predisposes patients to HLRCC-associated RCC. These tumors are notoriously aggressive and often exhibit early metastases. HLRCC results from germline mutations in...

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PMID: 32744123
DOI: 10.1080/14728222.2020.1804862

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