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Article

Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research.

Seminars in cancer biology - 1 Apr 2020

Ooi Aikseng

Abstract excerpt

Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is an autosomal dominant hereditary cancer syndrome with incomplete penetrance. It is caused by a germline amorphic allele of the FH gene, which encodes the TCA cycle enzyme, fumarate hydratase (FH). HLRCC patients are genetically predisposed to develop skin leiomyomas, uterine fibroids, and the aggressive kidney cancer of type 2 papillary morphology....

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leiomyomatosis

Share to Neoplastic Syndromes, Hereditary

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Share to Uterine Neoplasms

Source

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Identifiers

PMID: 31689495
DOI: 10.1016/j.semcancer.2019.10.016
PMCID: PMC7078051

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