Article

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

2023-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) lead to fumarate accumulation and cause hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC is a rare, inherited disease characterized by the development of non-cancerous smooth muscle tumors of t...

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Literature Corpus work: 6f555b04-61b7-5652-b7f7-f55855b679db
DOI: 10.1101/2023.04.10.536262

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