Article

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite

2020-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Metabolism and signaling intersect in the genetic cancer syndrome hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a disease in which mutation of the TCA cycle enzyme fumarate hydratase (FH) causes hyperaccumulation of fumarate. This electrophilic oncometabolite can alter gene activity at the level of transcription, via reversible inhibition of epigenetic dioxygenases, as well as post...

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Literature Corpus work: 546c81d5-06c3-52e1-ac2c-9e572253ca50
DOI: 10.1101/2020.06.25.171843

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