Article
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
Cell reports - 30 May 2013
Adam Julie, Yang Ming, Bauerschmidt Christina, Kitagawa Mitsuhiro, O'Flaherty Linda, Maheswaran Pratheesh, Özkan Gizem, Sahgal Natasha, Baban Dilair, Kato Keiko, Saito Kaori, Iino Keiko, Igarashi Kaori, Stratford Michael, Pugh Christopher, Tennant Daniel A, Ludwig Christian, Davies Benjamin, Ratcliffe Peter J, El-Bahrawy Mona, Ashrafian Houman, Soga Tomoyoshi, Pollard Patrick J
Abstract excerpt
The identification of mutated metabolic enzymes in hereditary cancer syndromes has established a direct link between metabolic dysregulation and cancer. Mutations in the Krebs cycle enzyme, fumarate hydratase (FH), predispose affected individuals to leiomyomas, renal cysts, and cancers, though the respective pathogenic roles of mitochondrial and cytosolic FH isoforms remain undefined. On the basis of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.