Article

Conditional covalent lethality driven by oncometabolite accumulation

2022-04-26

Abstract excerpt

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase ( FH ). Inactivation of FH causes accumulation of the electrophilic oncometabolite fumarate. In the absence of methods for reactivation, tumor suppressors can be targeted via identification of synthetic lethal interactions using genetic screens. Inspired by...

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Literature Corpus work: 389e9f97-7ee1-5bf6-814d-446021799572
DOI: 10.1101/2022.04.26.489575

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