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Article

Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients.

Scientific reports - 30 Apr 2021

Bateman Nicholas W, Tarney Christopher M, Abulez Tamara, Soltis Anthony R, Zhou Ming, Conrads Kelly, Litzi Tracy, Oliver Julie, Hood Brian, Driggers Paul, Viollet Coralie, Dalgard Clifton, Wilkerson Matthew, Catherino William, Hamilton Chad A, Darcy Kathleen M, Casablanca Yovanni, Al-Hendy Ayman, Segars James, Conrads Thomas P, Larry Maxwell G

Abstract excerpt

Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC (n = 16; FH-mutation confirmed) and non-syndromic (NS) patients (n = 12) identified a significantly higher protein:transcript correlation in HLRCC (R = 0.35) vs. NS ULMs (R = 0.242, MWU...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33931688
DOI: 10.1038/s41598-021-88585-x
PMCID: PMC8087684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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