Computational Saturation Screen Reveals the Landscape of Mutations in Human Fumarate Hydratase.

Abstract excerpt

Single amino acid substitutions within protein structures often manifest with clinical conditions in humans. The mutation of a single amino can significantly alter protein folding and stability, or change protein dynamics to influence function. The chemical engineering field has developed a large toolset for predicting the influence of point mutations with the aim of guiding the design of improved and more stable...

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