Article

Acetyl transferase EP300 deficiency leads to chronic replication stress mediated by defective fork protection at stalled replication forks

2023-04-29

Abstract excerpt

Mutations in the epigenetic regulator and global transcriptional activator, E1A binding protein (EP300), is being increasingly reported in aggressive hematological malignancies including adult T-cell leukemia/lymphoma (ATLL). However, the mechanistic contribution of EP300 dysregulation to cancer initiation and progression are currently unknown. Independent inhibition of EP300 in human cells results in the differen...

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Literature Corpus work: c2bfc529-fdaa-535b-8736-5d9c2cd08916
DOI: 10.1101/2023.04.29.538781

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