Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.

Epigenomics - 1 Feb 2025

Xu Longxia, Xuan Hongwen, Shi Xiaobing

Abstract excerpt

p300 (E1A binding protein 300) and CBP (CREB-binding protein) are critical regulators of chromatin dynamics and gene expression, playing essential roles in various cellular processes, including proliferation, differentiation, apoptosis, and immune responses. These homologous histone acetyltransferases (HATs) function as transcriptional co-activators by acetylating histones and non-histone proteins. p300/CBP is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to CREB-Binding Protein
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

Share to Mutation

Share to Neoplasms

Share to p300-CBP Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39929233
DOI: 10.1080/17501911.2024.2447807
PMCID: PMC11812348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.PMID 39929233Read ↗

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read ↗

CBP/p300 acetyltransferase activity in hematologic malignancies.Semantic proximity Read ↗

Genetic mutations and inhibitors of p300 and CBP.Semantic proximity Read ↗

p300/CBP proteins: HATs for transcriptional bridges and scaffoldsSemantic proximity Read ↗

Emerging roles of p300/CBP in autophagy and autophagy-related human disordersSemantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.Semantic proximity Read ↗

Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression.Semantic proximity Read ↗

Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemiaSemantic proximity Read ↗

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional MechanismsSemantic proximity Read ↗

p300/CBP and cancerSemantic proximity Read ↗

Characteristics of anticancer activity of CBP/p300 inhibitors – Features of their classes, intracellular targets and future perspectives of their application in cancer treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.