Article
EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection.
Nature communications - 7 Dec 2025
Barreto-Galvez Angelica, Niljikar Mrunmai, Gagliardi Julia Elizabeth, Guzman Carolina Plasencia, Zhang Ranran, Kumar Vasudha, Juwarwala Aastha, Pradeep Archana, Saxena Ankit, Montagna Cristina, Mittal Priya, Gerhardt Jeannine, Xia Bing, Cao Jian, Kataoka Keisuke, Durbin Adam David, Qi Jun, Ye B Hilda, Madireddy Advaitha
Abstract excerpt
Mutations in the global transcriptional activator EP300/KAT3B are being reported in aggressive malignancies. However, the mechanistic contribution of EP300 dysregulation to cancer is currently unknown. While EP300 has been implicated in regulating cell cycle and DNA replication, the role of EP300 in maintaining replication fork integrity has not been studied. Here, using EP300-mutated adult T-cell...
Topics
Join the communities discussing this publication.