Article

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

2022-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Genomic instability fuels genomic alterations that befit cancer cells with necessary adaptations to keep proliferating and overcome the impact of host anti-tumor immunity and cytotoxic therapy. Since DNA breaks are required for genomic rearrangements to take place, we hypothesized that dysregulated nuclease activity mediates genomic instability in cancer. Using an integrated genomics protocol, w...

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Identifiers and source

Literature Corpus work: 24248880-e08d-54a9-a092-8882a960cf86
DOI: 10.1101/2022.04.20.488830

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