Article

Gating Mechanism of the Human Connexin 45 Gap Junction Channel

2026-05-07

Abstract excerpt

Gap junction channels formed by the 21-member human connexin family enable direct intercellular exchange of ions and small signaling metabolites, coordinating electrical coupling across cardiac, neural and epithelial tissues. Connexin 45 (Cx45), encoded by GJC1, mediates impulse conduction in the atrioventricular node, His bundle, and Purkinje fibers, where disease-linked mutations cause progressive atrioventricul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2b0e551-8938-5e54-aaa5-308e155a8c7e
DOI: 10.64898/2026.05.04.722611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gating Mechanism of the Human Connexin 45 Gap Junction ChannelDOI 10.64898/2026.05.04.722611Read

Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease.Semantic proximity Read

Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels.Semantic proximity Read

Research progress of connexin 43 in cardiovascular diseasesSemantic proximity Read

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.Semantic proximity Read

Quantifying Electrostatic Control of Docking and Binding Energetics in Functional Cx36 Gap JunctionsSemantic proximity Read

Structure of native lens connexin 46/50 intercellular channels by cryo-EM.Semantic proximity Read

Gap junction channel structure in the early 21st century: facts and fantasies.Semantic proximity Read

Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket.Semantic proximity Read

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics SimulationsSemantic proximity Read

The First Extracellular Domain Plays an Important Role in Unitary Channel Conductance of Cx50 Gap Junction Channels.Semantic proximity Read

Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutationsSemantic proximity Read

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding siteSemantic proximity Read