Article
Gap junction channel structure in the early 21st century: facts and fantasies.
Current opinion in cell biology - 1 Oct 2007
Yeager Mark, Harris Andrew L
Abstract excerpt
Gap junction channels connect the cytoplasms of adjacent cells through the end-to-end docking of single-membrane structures called connexons, formed by a ring of six connexin monomers. Each monomer contains four transmembrane alpha-helices, for a total of 24 alpha-helices in a connexon. The fundamental structure of the connexon pore is probably similar in unpaired connexons and junctional channels, and for...
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