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Article

The First Extracellular Domain Plays an Important Role in Unitary Channel Conductance of Cx50 Gap Junction Channels.

PloS one - 1 Jan 2015

Tong Xiaoling, Aoyama Hiroshi, Sudhakar Swathy, Chen Honghong, Shilton Brian H, Bai Donglin

Abstract excerpt

Gap junction (GJ) channels provide direct passage for ions and small molecules to be exchanged between neighbouring cells and are crucial for many physiological processes. GJ channels can be gated by transjunctional voltage (known as Vj-gating) and display a wide range of unitary channel conductance (γj), yet the domains responsible for Vj-gating and γj are not fully clear. The first extracellular domain (E1) of...

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Identifiers

PMID: 26625162
DOI: 10.1371/journal.pone.0143876
PMCID: PMC4666595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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