Article

Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations

2020-11-30

Abstract excerpt

<h4>Summary</h4> Cardiac ryanodine receptor (RyR2) is a large Ca 2+ release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in the heart. RyR2 is activated by Ca 2+ and RyR2 mutations are implicated in severe arrhythmogenic diseases. Yet, the structural basis underlying channel opening and how mutations affect the channel remain unknown. Here, we addressed gating mech...

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Literature Corpus work: 82fc35f9-f402-5618-a9b8-129274e07e85
DOI: 10.1101/2020.11.30.401026

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