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Article

Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels.

Journal of molecular and cellular cardiology - 1 Jan 2016

Jassim Arjewan, Aoyama Hiroshi, Ye Willy G, Chen Honghong, Bai Donglin

Abstract excerpt

Gap junction (GJ) channels provide low resistance passages for rapid action potential propagation in the heart. Both connexin40 (Cx40) and Cx43 are abundantly expressed in and frequently co-localized between atrial myocytes, possibly forming heterotypic GJ channels. However, conflicting results have been obtained on the functional status of heterotypic Cx40/Cx43 GJs. Here we provide experimental evidence that the...

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Identifiers

PMID: 26625713
DOI: 10.1016/j.yjmcc.2015.11.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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