Article
Structure of native lens connexin 46/50 intercellular channels by cryo-EM.
Nature - 1 Dec 2018
Myers Janette B, Haddad Bassam G, O'Neill Susan E, Chorev Dror S, Yoshioka Craig C, Robinson Carol V, Zuckerman Daniel M, Reichow Steve L
Abstract excerpt
Gap junctions establish direct pathways for cell-to-cell communication through the assembly of twelve connexin subunits that form intercellular channels connecting neighbouring cells. Co-assembly of different connexin isoforms produces channels with unique properties and enables communication across cell types. Here we used single-particle cryo-electron microscopy to investigate the structural basis of connexin...
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