Article

Quantifying Electrostatic Control of Docking and Binding Energetics in Functional Cx36 Gap Junctions

2025-10-26

Abstract excerpt

Connexin36 (Cx36) is broadly expressed in neurons and serves as the principal protein that forms interneuronal gap junctions (GJs), also known as electrical synapses. Recent high-resolution structures of human Cx36 GJ have revealed crucial electrostatic interactions (ESIs) of charged residues between two docked Cx36 hemichannels at the second extracellular (E2) loops. Despite their structural importance, the mecha...

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Literature Corpus work: 9e9aa574-1388-5c67-beb1-e2620e8d591b
DOI: 10.1101/2025.10.25.684567

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