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Article

Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket.

Biological research - 23 May 2024

Villanelo Felipe, Minogue Peter J, Maripillán Jaime, Reyna-Jeldes Mauricio, Jensen-Flores Joaquin, García Isaac E, Beyer Eric C, Pérez-Acle Tomás, Berthoud Viviana M, Martínez Agustín D

Abstract excerpt

BACKGROUND: Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated in members of the α-, γ-, δ-, and ε-subfamilies. We studied connexin50 (Cx50) as a representative of the α-subfamily, because its structure has been determined and mutations of Cx50 are among the...

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Identifiers

PMID: 38783330
DOI: 10.1186/s40659-024-00501-5
PMCID: PMC11112876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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