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Article

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.

Nature communications - 20 May 2022

Kobayashi Takuya, Tsutsumi Akihisa, Kurebayashi Nagomi, Saito Kei, Kodama Masami, Sakurai Takashi, Kikkawa Masahide, Murayama Takashi, Ogawa Haruo

Abstract excerpt

Cardiac ryanodine receptor (RyR2) is a large Ca2+ release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in the heart. RyR2 is activated by Ca2+ and RyR2 mutations are implicated in severe arrhythmogenic diseases. Yet, the structural basis underlying channel opening and how mutations affect the channel remains unknown. Here, we address the gating mechanism of RyR2 by...

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Identifiers

PMID: 35595836
DOI: 10.1038/s41467-022-30429-x
PMCID: PMC9123176

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