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Article

Connexin45 (GJC1) loss-of-function mutation contributes to familial atrial fibrillation and conduction disease.

Heart rhythm - 1 May 2021

Li Ruo-Gu, Xu Ying-Jia, Ye Willy G, Li Yan-Jie, Chen Honghong, Qiu Xing-Biao, Yang Yi-Qing, Bai Donglin

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) represents the most common clinical cardiac arrhythmia and substantially increases the risk of cerebral stroke, heart failure, and death. Although causative genes for AF have been identified, the genetic determinants for AF remain largely unclear. OBJECTIVE: This study aimed to investigate the molecular basis of AF in a Chinese kindred. METHODS: A 4-generation family with...

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Source

Identifiers

PMID: 33429106
DOI: 10.1016/j.hrthm.2020.12.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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