Article

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

2024-03-29

Abstract excerpt

Extrachromosomal DNA (ecDNA) presents a major challenge for precision medicine, contributing to poor survival for patients with oncogene-amplified tumours. EcDNA renders tumours resistant to targeted treatments by facilitating massive transcription of oncogenes and rapid genome evolution. At present, there are no ecDNA- specific treatments. Here we show that enhancing transcription replication conflict enables tar...

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Literature Corpus work: c2aadaf6-7a02-5af2-ba46-2dab2c8bd753
DOI: 10.1101/2024.03.29.586681

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