Article

Frequent extrachromosomal oncogene amplification drives aggressive tumors

2019-11-28

Abstract excerpt

Extrachromosomal DNA (ecDNA) amplification promotes high oncogene copy number, intratumoral genetic heterogeneity, and accelerated tumor evolution 1–3 , but its frequency and clinical impact are not well understood. Here we show, using computational analysis of whole-genome sequencing data from 1,979 cancer patients, that ecDNA amplification occurs in at least 26% of human cancers, of a wide variety of histologic...

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Literature Corpus work: 2c7811a2-fb02-5132-a73b-af38e94cdd51
DOI: 10.1101/859306

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